To identify DnaA interactors relevant to this phenotype, we perform the first genome-wide biochemical mapping of DnaA binding sites in mycobacteria which reveals a DnaA interaction site that is the target of recurrent mutation in clinical strains. tuberculosis survival during isoniazid treatment via reduced expression of katG, the activator of isoniazid. We demonstrate that these dnaA mutations specifically enhance M.
Through a genome wide association study, we show that non-synonymous mutations in dnaA, which encodes an essential and highly conserved regulator of DNA replication, are associated with drug resistance in clinical M. Clinical strains of Mycobacterium tuberculosis exhibit extensive quantitative variation in antibiotic susceptibility but the genetic basis behind this spectrum of drug susceptibility remains ill-defined. However, reduced susceptibility to antibiotics-even below this breakpoint-is associated with poor treatment outcomes in the clinic, including in tuberculosis.
Want updates on new book releases? Follow me on Facebook or on my author page: JessicaGraysonAuthor.Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. In addition to reading and writing romance, she loves swimming, chai and dark chocolate. She lives with her husband, cat and dog in the San Antonio, TX area. USA Today bestselling author, Jessica Grayson writes scifi and fantasy romance about strong heroines and the otherworldly heroes that cannot help but fall in love with them. Only available as part of the Realm of Darkness Boxset available for preorder now on Amazon and other retailers for only 99c/77p! Now, I find myself wondering: What would it be like if I allowed myself to fall? But the more time we spend together, I find myself captivated by this man who would be my husband and king. Our people have ben enemies for hundreds of years. His people believe that a soul bond woven by fate cannot be undone. He spares my life, but he refuses to let me go.
The moment our eyes meet, the King claims I am his Fated One-his Khio’ri. When I accidentally wander too close to the veil, I’m captured and brought before him. He is known throughout the seven kingdoms as a fierce and lethal warrior.
0 kommentar(er)
